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Updated: Jun 28, 2025

Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists
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Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists

Published on: November 15, 2013

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核受体核心抑制剂非法定地驱动葡萄糖皮质体受体依赖肝脏葡萄糖生成的激活

Amy K Hauck1, Rashid Mehmood1, Bryce J Carpenter1

  • 1Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Nature metabolism
|April 15, 2024
PubMed
概括

核受体核心抑制剂 (NCoRs) 在肝脏代谢中具有令人惊的非正规激活作用. 由于阻断基因激活,NCoR1和NCoR2的损失会导致脂肪肝和低血糖症.

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