对诺普拉桑耐烧胃炎患者和对质子抑制剂耐药患者之间的差异
Tomoaki Matsumura1, Michiko Sonoda2, Kenichiro Okimoto2
1Department of Gastroenterology, Graduate School of Medicine, Chiba University, Inohana 1-8-1, Chiba, 260-8670, Japan. matsumura@chiba-u.jp.
Digestive diseases and sciences
|April 15, 2024
概括
与PPI耐药性胃灼热患者相比,未经证实的经历过耐火性胃灼热的GERD患者表现出更多症状,包括功能性消化不良和IBS,与耐PPI耐火性胃灼热患者相比. 这突显了耐火GERD表现的差异.
科学领域:
- 胃肠病学 胃肠病学
- 与酸相关的疾病 酸相关的疾病
- 耐火性GERD的管理方法
背景情况:
- 诺普拉桑提供强大的酸抑制,超过质子抑制剂 (PPI).
- 未经证实的胃食道逆流性疾病 (GERD) 带来了诊断挑战.
- 将耐火性胃灼热与vonoprazan与PPI进行比较对于治疗策略至关重要.
研究的目的:
- 为了评估vonoprazan在未经证明的GERD患者中的作用.
- 为了比较vonoprazan耐火性胃灼热与PPI耐火性胃灼热.
- 为了确定症状概况和诊断发现的差异.
主要方法:
- 研究了104名患有耐火性胃灼热的患者 (52名vonoprazan,52名PPI) 没有侵蚀性食道炎.
- 药物停用后进行了联合多通道内阻抗-pH (MII-pH) 测试.
- 患者背景,症状得分,MII-pH和高分辨率测量结果进行了比较.
主要成果:
- 诺普拉赞组报告了更高的GERD症状,腹痛和腹.
- 在vonoprazan组中,MII-pH显示了真正非侵蚀性反流性疾病 (NERD) 的更高率 (40.4%与26.9%相比).
- 功能性胃灼热在PPI组中更为普遍 (55.8%对42.3%).
结论:
- 未经证实的GERD与vonoprazan-refractory胃灼热呈现出更广泛的症状,包括功能性消化不良和IBS.
- 这表明耐火性GERD有不同的潜在机制或患者个人资料.
- 对耐火性GERD表型的进一步调查是有必要的.
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