在甲状腺轨道病的斑点和光盘血管密度的比较:一个比较的八度研究
Izlem Yildiz1, Senay Asik Nacaroglu2, Gamze Ozturk Karabulut2
1Beyoglu Eye Training and Research Hospital, University of Health Sciences, Bereketzade Street Number:2, Beyoglu, Istanbul, Turkey. izlemyildiz@gmail.com.
International ophthalmology
|April 15, 2024
概括
类固醇治疗改善了活跃甲状腺轨道病变 (TO) 患者的微血管密度,显示了视网膜和视神经 perfusion 的增加. 光学连贯断层扫描血管造影 (OCTA) 有助于监测TO的进展和治疗的有效性.
科学领域:
- 眼科医生 眼科 眼科
- 内分泌学 在内分泌学.
- 医疗成像医学成像
背景情况:
- 甲状腺轨道病 (TO) 涉及眼的炎症和结构变化.
- 视网膜和视神经的微血管变化可能发生在TO.
- 光学连贯断层扫描血管造影 (OCTA) 允许对眼血管系统进行非侵入性可视化.
研究的目的:
- 在类固醇治疗前后评估活跃TO患者的微血管和结构变化.
- 将这些变化与不活跃的TO患者和健康对照进行比较.
- 评估OCTA在监测TO中的实用性.
主要方法:
- 一项涉及17名活跃TO患者,54名不活跃TO患者和30名健康对照者的横截面研究.
- OCTA用于测量中央黄斑厚度 (CMT),状细胞层-内状层 (GCL-IPL) 厚度,中央胆道层厚度 (CCT),视网膜神经纤维层厚度 (RNFL) 和血管密度 (SCP,DCP,choriocapillaris).
- 在活跃的TO患者中,在12周的类固醇治疗课程之前和之后进行了测量.
主要成果:
- 活跃的TO患者与不活跃的TO和对照组相比,显示出明显较低的斑点和周周血管密度.
- 在类固醇治疗后,活跃的TO患者表现出CMT和CCT的降低,以及GCL-IPL厚度的增加.
- 治疗后的OCTA显示了斑点和周周毛细管表面毛细管 (SCP) 和深毛细管 (DCP) 血管密度的显著增加.
结论:
- 活性甲状腺轨道病与眼部微血管密度降低有关.
- 类固醇治疗可以显著改善活跃TO的微血管输液.
- OCTA是一种有价值的非侵入性工具,用于早期检测,治疗监测和对TO患者的管理.
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