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在炎症性肠病中介质素17的水平及其与疾病活动的关系
Ayman Menesy1, Mohamed Hammad2, Salah Aref3
1Professor of Internal Medicine, Hepatology and Gastroenterology, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
BMC gastroenterology
|April 15, 2024
概括
在患有炎症性肠病 (IBD),包括性结肠炎和克罗恩病的患者中,血清中介质素-17 (IL-17) 水平升高. 然而,这种增加与疾病活动指标无关.
科学领域:
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
- 临床医学 临床医学
背景情况:
- 炎症性肠病 (IBD) 是一种慢性胃肠道疾病,其特征是逐渐的肠损伤和免疫失调.
- 在T助手17 (Th17) 细胞因子生产中的不平衡,如IL-17,与IBD的发病有关.
- 了解IL-17在IBD中的作用对于管理这种终身疾病至关重要.
研究的目的:
- 在被诊断患有IBD的患者中检查interleukin-17 (IL-17) 的血清水平.
- 确定血清IL-17水平与IBD活性之间的关系.
- 评估血清IL-17的诊断潜力,以区分IBD与健康对照.
主要方法:
- 进行了一项病例控制研究,涉及18-65岁的患有性结肠炎 (UC) 或克罗恩病 (CD) 的患者和健康的对照.
- 评估IBD疾病活动是使用梅奥评分对UC和克罗恩病活动指数 (CDAI) 对CD.
- 使用ELISA测量血清IL-17水平,以及其他炎症标志物如CRP,ESR和便calprotectin.
主要成果:
- 与对照组相比,UC和CD患者的血清IL-17水平显著升高 (P < 0.001).
- IL-17水平与梅奥得分或CDAI没有相关性,但与UC中的结肠炎症程度和CD中的疾病类型有显著的相关性.
- 血清IL-17显示出高诊断准确度 (AUC=0.993),截止值为32ppg/ml,达到97.5%的灵敏度和95.2%的特异性.
结论:
- 在患有IBD特征性结肠炎症的患者中,血清IL-17显著增加.
- 在IBD患者中,升高的IL-17水平与当前的疾病活性评分 (Mayo或CDAI) 并没有直接相关.
- 血清IL-17显示出潜力作为检测IBD的生物标志物,独立于疾病活性测量.
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