在秘鲁,癌症病例和因可能可修改的风险因素而导致的死亡人数比例
Jhony A De La Cruz-Vargas1, Willy Ramos2, Willer Chanduví2
1Instituto de Investigaciones en Ciencias Biomédicas (INICIB), Universidad Ricardo Palma, Lima, Perú. jhony.delacruz@urp.edu.pe.
BMC cancer
|April 15, 2024
概括
在秘鲁,在COVID-19大流行之前,可修改的风险因素导致了38.5%的癌症病例和43.4%的癌症死亡. 致癌性感染,烟草和肥胖是预防癌症负担的主要原因.
科学领域:
- 流行病学 流行病学
- 公共卫生 公共卫生
- 在瘤学瘤学.
背景情况:
- 关于拉丁美洲癌症的人口归因分数 (PAF) 的数据有限.
- 之前的秘鲁研究已经探讨了各种风险因素和疾病的PAF.
- 本研究量化了2018年秘鲁癌症可修改风险因素的PAF.
研究的目的:
- 估计秘鲁因可修改风险因素而导致的癌症病例和死亡的比例.
- 在COVID-19大流行之前提供基线数据.
- 为预防癌症的公共卫生战略提供信息.
主要方法:
- 采用了生态研究设计.
- 数据包括2018年秘鲁的暴露流行率,相对风险和癌症统计数据.
- 用帕金公式与蒙特卡洛模拟来计算PAF和置信区间.
主要成果:
- 可修改的风险因素占秘鲁新发癌症病例的38.5%和癌症死亡的43.4% (人口≥15岁).
- 可归因于癌症:25308例病例和14839例死亡.
- 主要因素:HPV感染,烟草使用和Helicobacter pylori感染.
结论:
- 秘鲁癌症负担的很大一部分归因于可修改的风险因素.
- 致癌性感染 (HPV,H. pylori) 是可预防的癌症的主要原因.
- 针对生活方式和感染的公共卫生干预措施对于癌症控制至关重要.
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