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在宫癌的放射治疗期间,骨盆目标体积的分数间运动,每日代圆束计算断层扫描
Zheng Zeng1, Jiawei Zhu1, Zhiqun Wang1
1Department of Radiation Oncology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, 100730, Beijing, China.
Radiation oncology (London, England)
|April 15, 2024
概括
放射治疗期间的子宫体运动大于宫运动,增加了在标准边际错过临床目标体积 (CTV) 的风险. 个性化边缘对于提高宫癌放射治疗精度至关重要,特别是在早期的T阶段.
科学领域:
- 在瘤学瘤学.
- 辐射瘤学 辐射瘤学
- 医疗成像医学成像
背景情况:
- 宫癌的放射治疗通常使用很大的边缘来解释瘤回归和器官运动.
- 子宫和子宫的间断运动可能会影响目标体积覆盖.
- 准确评估这些运动对于优化治疗疗效至关重要.
研究的目的:
- 在接受放射治疗的宫癌患者中量化子宫 (CTV-U) 和子宫 (CTV-C) 的间断运动.
- 为了评估标准规划边际的临床目标体积 (CTV) 的覆盖范围.
- 为了确定早期瘤阶段是否影响运动和边际要求.
主要方法:
- 分析了15名宫癌患者的303次代形束计算断层扫描 (iCBCT) 扫描.
- 在每个ICBCT扫描中,CTV-U和CTV-C的划分.
- 测量CTV-U和CTV-C偏移的前后,上下和横向方向.
- 评估目标覆盖率使用规划CTV的统一扩展.
主要成果:
- 子宫 (CTV-U) 运动在所有方向上都比子宫 (CTV-C) 运动更大,前后和侧面的位移显著.
- 早期T阶段 (T1) 患者表现出较大的CTV-U和CTV-C运动.
- 一个15毫米统一的CTV利率未能覆盖CTV-U的11.1%和CTV-C的2.2%的部分.
- 与计划的CTV相比,CTV-U和CTV-C的平均体积变化分别为150%和51%.
结论:
- 在放射治疗期间,子宫体运动比宫运动更明显.
- 标准规划利不足以保证CTV的覆盖,因为有大量的分派间运动.
- 个性化放射治疗边缘化策略是必要的,以提高治疗的准确性,特别是在早期的宫癌.
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