依赖于STING的训练免疫力有助于通过mTOR信号传递对宿主防御Clostridium perfringens感染
Zhen-Zhen Liu1, Cheng-Kai Zhou1, Xiao-Qi Lin1
1State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, Institute of Zoonosis, and College of Veterinary Medicine, Jilin University, Changchun, 130062, China.
Veterinary research
|April 15, 2024
概括
干扰素基因 (STING) 刺激剂依赖的训练免疫增强了对宿主抗克洛斯特病毒感染的防御能力. 这种保护通过mTOR信号通路进行介导,改善细菌清除.
科学领域:
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
- 分子生物学分子生物学
背景情况:
- 克洛斯特里透感染对食品安全和农业构成重大威胁.
- 与C. perfringens的宿主-病原体相互作用背后的分子机制尚不清楚.
研究的目的:
- 调查训练免疫在保护C. perfringens感染中的作用.
- 阐明参与这种保护性反应的分子通路,特别是STING和mTOR信号传递.
主要方法:
- 利用热杀死的Candida albicans (HKCA) 诱导小鼠腹巨细胞 (PM) 的训练免疫力.
- 管理的STING激动剂DMXAA,以评估其在训练免疫力和宿主耐药性中的作用.
- 使用基因缺陷和药理抑制方法研究了STING和mTOR信号通路的参与.
- 在体外和体内评估了细菌的细胞化,清除和细胞因子的产生.
主要成果:
- 通过HKCA培训,增强了细菌的细胞能力和C. perfringens的清除.
- HKCA训练激活了STING信号,而STING激活赋予了对C. perfringens的抵抗力.
- 丁缺乏症会损害训练免疫力,减少细胞因子分泌,细胞分裂和杀死细菌.
- 激活的STING信号与增加的AKT/mTOR/HIF1α表达相关.
- 拉帕素的mTOR抑制降低了对C. perfringens挑战的训练反应.
结论:
- 依赖于STING的训练免疫力提供了对C. perfringens感染的保护.
- mTOR信号通路对于调解对C. perfringens的STING诱导训练免疫力至关重要.
- 这些发现为对抗C. perfringens的宿主防御机制提供了新的见解.
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