在肝脏相关疾病的发病过程中LncRNA NEAT1
Raed Obaid Saleh1, Adnan Taan Alkhafaji2, Jaafaru Sani Mohammed3
1Department of Medical Laboratory Techniques, Al-Maarif University College, Al-Anbar, Iraq.
Cell biochemistry and function
|April 16, 2024
概括
核斑组合转录1 (NEAT1),是一种长非编码RNA,与肝脏疾病有关. 它的失调导致肝癌和纤维化,这表明NEAT1是治疗点.
科学领域:
- 分子生物学分子生物学
- 遗传学 遗传学 是一个
- 肝病学 肝病学是一种肝病学.
背景情况:
- 核斑组合转录1 (NEAT1) 是一种长非编码RNA (lncRNA),在哺乳动物中表达.
- 改变NEAT1水平与各种肝脏疾病有关,包括癌症,脂肪肝,纤维化,肝炎和缺血.
- NEAT1作为一个竞争的内源RNA (ceRNA) 功能,菌微RNA (miRNAs) 调节细胞过程.
研究的目的:
- 审查NEAT1在肝脏相关疾病中的分子机制.
- 突出NEAT1在肝癌和纤维化病原发生中的作用.
- 引入NEAT1作为肝脏疾病的潜在治疗点.
主要方法:
- 文献综述和对现有NEAT研究进行综合研究1.
- 分析NEAT1的分子功能,包括其ceRNA活性.
- 讨论NEAT1在肝脏疾病进展中的参与.
主要成果:
- 升高的NEAT1表达与肝癌细胞的增多,迁移,血管生成和上皮-介质细胞过渡 (EMT) 相相关.
- NEAT1的上调有助于肝纤维化的发病.
- 讨论了NEAT1在急性肝衰竭和非酒精性脂肪性肝病 (NAFLD) 中的特定作用.
结论:
- NEAT1在各种肝脏疾病背后的分子机制中发挥着重要作用.
- 向NEAT1可能为肝脏疾病提供一种新的治疗策略.
- 对NEAT1的功能进行进一步的研究可能会导致改善肝病的治疗方法.
更多相关视频
07:23Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
Published on: May 30, 2025
288
08:41Novel In Vivo Micro-Computed Tomography Imaging Techniques for Assessing the Progression of Non-Alcoholic Fatty Liver Disease
Published on: March 24, 2023
1.1K
相关概念视频
02:39lncRNA - Long Non-coding RNAs
8.6K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
8.6K
03:18Non-LTR Retrotransposons
11.5K
As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
11.5K
01:41Non-Canonical Wnt Signaling Pathways
7.3K
Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
7.3K
02:54Canonical Wnt Signaling Pathway
8.7K
The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which...
8.7K
02:55The Nucleolus
8.8K
The nucleolus is the most prominent substructure of the nucleus. When it was first discovered, it was considered to be an isolated organelle that forms fibrils and granules. In 1931, the relationship between the nucleolus and chromosomes was first described by Heitz. He observed that the appearance and size of nucleolus varies depending on the stage of the cell cycle. He also noticed constricted regions on different chromosomes clustered together at definite cell cycle stages. These regions,...
8.8K
01:22MicroRNAs
3.0K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.0K