黄素对与激素相关的内分泌功能障碍的多方面的生理和治疗影响:综合性综述
Xiuying Wang1, Wei Zhang1, Shengxue Zhou1
1College of Chinese Medicine, Jilin Agricultural Science and Technology College, Jilin, China.
Phytotherapy research : PTR
|April 16, 2024
概括
从黄中提取的黄,通过影响细胞信号传递和对抗炎症和氧化损伤,显示出对各种疾病的治疗前景. 需要进一步的研究来探索其对抗衰老和退行性疾病的潜力.
科学领域:
- 药理学和自然产品的研究.
- 分子生物学分子生物学
- 内分泌学 在内分泌学.
背景情况:
- 50年来,黄 (Curcuma longa) 中的黄 (Curcumin (Cur)) 已被研究为治疗用途.
- 最近的临床试验 (25年) 提供了关于Cur的疗效和安全性的见解.
- 它对人类疾病的影响,特别是内分泌功能,是一个日益增长的研究领域.
研究的目的:
- 审查关于黄素在各种人类疾病中的治疗潜力的临床证据.
- 为了阐明黄素的药理动力学和安全性概况.
- 探索黄素在内分泌信号传递和疾病预防中的分子机制.
主要方法:
- 过去25年来临床试验的系统审查.
- 对库尔库明作用背后的分子机制的分析.
- 专注于内分泌腺和相关的信号通路.
主要成果:
- 黄素在各种人类疾病中表现有前途,对内分泌腺体有显著影响.
- 关键机制包括改变激素水平,抑制细胞因子/基因表达,调节转录因子.
- 黄素通过抑制抗瘤基因和阻碍瘤促进,表现出抗氧化和抗炎性质.
结论:
- 黄素显示出作为一种用于管理衰老和退行性疾病的天然药物的潜力.
- 它对细胞信号通路和保护机制的影响需要进一步研究.
- 建议进行专门的研究,以充分实现黄素的治疗应用.
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