橄水会影响学龄儿童的肺功能/结构异常,患有支气管肺形
Jeong Eun Shin1, Soon Min Lee2, Mi-Jung Lee3
1Department of Pediatrics, Severance Children's Hospital, Yonsei University College of Medicine, Seoul, Korea.
Clinical and experimental pediatrics
|April 16, 2024
概括
患有严重支气管肺功能障碍 (BPD) 的儿童即使没有症状,也会出现肺功能减弱和结构变化. 产前因素,如橄水症,与较差的结果有关,因此需要对受影响的个体进行延长的随访.
科学领域:
- 儿科肺病学 儿科肺病学
- 新生儿医学 新生儿医学
- 呼吸系统医学 呼吸系统医学
背景情况:
- 早期生活因素对早产婴儿肺部发育的影响尚未完全理解.
- 支气管肺功能障碍症 (BPD) 是早产婴儿的常见并发症,影响长期的肺部健康.
研究的目的:
- 调查BPD严重程度和围产期因素如何影响学龄儿童的肺功能和结构.
- 为了确定与早产幸存者的肺部结果受损相关的特定周产因子.
主要方法:
- 对早产儿 (出生于2005-2015年,年龄≥5岁) 的纵向队列研究.
- 根据NIH标准对BPD严重程度的分类.
- 进行了肺功能测试 (呼吸计) 和胸部CT扫描.
- 分析PFT结果,CT得分和围产因子.
主要成果:
- 与非/轻度BPD相比,严重BPD组的肺功能显著降低 (FEV1,FVC,FEV1/FVC,FEF25%-75%).
- 在严重的BPD组中观察到更高的CT得分,表明肺部异常.
- 产前的氧化水与肺功能减弱 (FEV1/FVC) 和CT得分增加有关.
结论:
- 患有严重BPD的学龄儿童有持续的气流限制和结构性肺损伤,通常无症状.
- 产前的氧水和长时间的机械通风是导致长期肺部不良结果的危险因素.
- 推对有严重BPD病史的早产婴儿进行延长的随访,特别是那些有产前并发症的早产婴儿.
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