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Updated: Jun 28, 2025

Determination of the Relative Potency of an Anti-TNF Monoclonal Antibody mAb by Neutralizing TNF Using an In Vitro Bioanalytical Method
16:07

Determination of the Relative Potency of an Anti-TNF Monoclonal Antibody mAb by Neutralizing TNF Using an In Vitro Bioanalytical Method

Published on: September 16, 2017

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成功的救援TNF-α阻断对Mycobacterium genavense - 相关的免疫复合炎症综合征:一个病例报告

Hugo Bes-Berlandier1, Margaux Garzaro1,2, Claire Rouzaud1

  • 1Service de Maladies Infectieuses et Tropicales, Hôpital Necker-Enfants-malades, Assistance publique-Hôpitaux de Paris, 149 rue de Sèvres, 75743, Paris, France.

Heliyon
|April 16, 2024
PubMed
概括

免疫复合炎症综合征 (IRIS) 在患有散播Mycobacterium genavense感染的免疫功能低下患者中可能对皮质类固醇耐药. 一种单克隆TNF-α抑制剂在两个晚发病病例中提供了有利的结果.

关键词:
案例报告案例报告爱丽丝爱丽丝是什么意思 IRIS是什么意思这就是Infliximab.单克隆抗TNF-α抗体的抗体菌根杆菌 genavense 的意思是什么

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Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
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