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帕金森病非运动症状的变化,在脑下体内深层大脑刺激后
Victor H Mandat1,2, Paweł R Zdunek1, Bartosz Krolicki1
1Department of Neurosurgery, Maria Sklodowska-Curie National Institute of Oncology, Warsaw, Poland.
World neurosurgery: X
|April 16, 2024
概括
脑下深层刺激 (STN DBS) 改善了帕金森病患者的非运动症状 (NMS). 年龄较小,疾病持续时间较短,临床状况较好,预测PD中NMS的结果更好.
科学领域:
- 神经学 神经学
- 神经外科 神经外科
- 运动障碍 运动障碍
背景情况:
- 脑下深层刺激 (STN DBS) 已被确立为帕金森病 (PD) 运动症状.
- 在PD中,STN DBS对非运动症状 (NMS) 的影响仍然不太了解和辩论.
研究的目的:
- 为了研究STN DBS对PD患者NMS的影响.
- 确定影响STN DBS后NMS改进的因素.
主要方法:
- 符合CAPSIT-PD标准的17名PD患者接受了STN DBS.
- 使用NMS尺度进行了非运动症状的评估,分别在手术前和手术后12个月.
- 记录了人口和临床数据,包括Hoehn-Yahr (H-Y) 阶段表.
主要成果:
- 总体而言,NMS尺度得分在12名患者 (71%) 中有所改善,平均下降25.67分.
- 在感知问题/幻觉 (Domain IV),心血管问题/跌倒 (Domain I) 和情绪/认知 (Domain III) 中观察到最显著的改善.
- 尿路 (第七域) 和各种 (第九域) 症状的恶化.
结论:
- STN DBS在PD患者中显示出对NMS的积极影响.
- 年龄较小,疾病持续时间较短和霍恩-雅尔得分较高与更好的NMS改善有关.
- 特定的NMS领域 (I,III,IV) 显示出最多的好处,而其他领域 (VII,IX) 可能会恶化.
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