患有阿尔茨海默氏症的人患抑郁症的风险:一项国家队列研究
Casey Crump1, Weiva Sieh2, Barbara G Vickrey3
1Departments of Family and Community Medicine and of Epidemiology The University of Texas Health Science Center Houston Texas USA.
Alzheimer's & dementia (Amsterdam, Netherlands)
|April 16, 2024
概括
患有阿尔茨海默氏症 (AD) 的人面临患抑郁症的风险是两倍以上. 这种风险增加在阿兹海默症诊断后的第一年是最高的,特别影响85岁及以上的人.
科学领域:
- 神经学 神经学
- 老年病的医生 老年病的医生
- 精神病学是一个精神病学.
背景情况:
- 抑郁症是已知的风险因素,也是阿尔茨海默病 (AD) 的潜在早期症状.
- 然而,在已经被诊断为阿尔茨海默病的个体中,患上抑郁症的后续风险仍未得到充分研究.
研究的目的:
- 与对照组相比,研究在被诊断患有阿尔茨海默氏症 (AD) 的人群中患有严重抑郁症的后续风险.
- 检查这种风险如何因性别,诊断时的年龄和诊断后的时间而异.
主要方法:
- 在瑞典 (1998-2017年) 进行的一项大型全国匹配队列研究,包括129,410名阿尔茨海默病患者和390,088名所有原因痴呆症患者,与3,900,880名没有先前抑郁症的对照进行了匹配.
- 考克斯回归分析被用来计算大抑郁症发病率的危险比率 (HRs) 到2018年.
主要成果:
- 患有阿尔茨海默症的个体呈现出13%的大型抑郁症的累积发病率,而对照组则为3%.
- 在对共变量进行调整后,患有AD的女性 (HR,2.21) 和男性 (HR,2.68) 患有重度抑郁症的风险是对照组的两倍以上.
- 诊断后的第一年内风险最高 (超过3倍),并且至少在三年内保持升高,在AD诊断时85岁以上的个体中观察到的风险最高.
结论:
- 被诊断为阿尔茨海默氏病 (AD) 或相关痴呆症的个人在随后患上抑郁症的风险明显增加.
- 对于被诊断患有AD和相关痴呆症的患者来说,对抑郁症的密切监测和及时干预至关重要.
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