在COVID-19大流行期间,按时服用德诺苏马布的剂量迅速恢复,但仍然低于最佳水平
Anna M Rzepka1, Angela M Cheung2,3, Sandra Kim1,4
1Leslie Dan Faculty of Pharmacy, Graduate Department of Pharmaceutical Sciences, University of Toronto, Toronto, ON M5S 3M2, Canada.
随着COVID-19的流行,骨质疏松症的正确时间的denosumab (骨密度药物) 治疗暂时被暂时中断. 虽然剂量恢复正常,但大约四分之一的患者仍然错过了按时注射,冒着骨折的风险.
科学领域:
- 老年学是一门学科.
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
背景情况:
- 在骨质疏松症管理中,每六个月及时服用登苏马布对于预防脊椎骨折至关重要.
- 停止或延迟德诺苏马布治疗可能会增加骨折风险.
研究的目的:
- 评估COVID-19大流行对代诺苏马布剂量时间的直接和持续影响.
- 分析不同患者群体和环境中的剂量模式.
主要方法:
- 使用安大略省药物福利局的66岁及以上成年人数据进行了中断时间序列分析.
- 该研究研究了2016年1月至2020年12月的每月按时服用德诺苏马布剂量 (183±30天),并追踪到2022年2月.
- 分析按用户类型 (新手,中级,成熟),护理环境 (社区,养老院) 和药物转换分层.
主要成果:
- 疫情前,该社区的登诺苏马布准时率因使用者类型而异 (64.9%新手,72.3%中级,78.0%成熟).
- 流行病导致所有社区用户类型 (-17.8%) 的按时剂量立即下降.
- 养老院居民的患者数量下降较小 (-3.2%),到2020年10月,按时剂量恢复到大流行前的水平,随后保持稳定,尽管大约25%的社区患者仍未得到充分治疗.
结论:
- 与疫情相关的德诺苏马布剂量中断是暂时的.
- 尽管康复,但在大量社区住院患者中,时间治疗率仍然低于最佳水平.
- 确保一致的,及时的denosumab管理仍然是骨质疏松症护理中的一个挑战.
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