多种人群中的蛋白质组分析改善了风险预测,并确定了2型糖尿病的新药标
Pang Yao1, Andri Iona1, Alfred Pozarickij1
1Clinical Trial Service Unit & Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, U.K.
Diabetes care
|April 16, 2024
概括
血蛋白质学和遗传分析确定了33种与2型糖尿病 (T2D) 风险相关的蛋白质. 这些蛋白质改善了T2D预测模型,并揭示了T2D预防和治疗的潜在新药标.
科学领域:
- 基因组学和蛋白质组学
- 代谢疾病 代谢疾病
- 生物标志物发现发现
背景情况:
- 2型糖尿病 (T2D) 构成一个重大的全球健康挑战.
- 确定新的生物标志物和治疗点对于T2D管理至关重要.
- 蛋白质组学和遗传学的综合分析为了解疾病机制提供了一种强大的方法.
研究的目的:
- 在中国队列中识别与发生T2D相关的血蛋白.
- 通过使用孟德尔随机化来评估已识别的蛋白质对T2D的因果关系.
- 评估这些蛋白质在改善T2D风险预测模型中的有用性.
主要方法:
- 来自中国Kadoorie生物银行 (CKB) 的约2000名参与者的2,923种蛋白质的等离子体蛋白质定位.
- 考克斯回归分析以确定与T2D事件相关的蛋白质.
- 基于蛋白质组的风险预测模型的开发和验证.
- 两个样本的孟德尔随机化和局部化分析以推断因果关系.
主要成果:
- 33种蛋白质与T2D风险显著相关 (FDR<0.05),包括IGFBP1,GHR和氨酶.
- 包括这些蛋白质改善了风险预测模型的AUC从0.77到0.88和NRI的38%.
- 门德尔的随机化支持ENTR1,LPL和PON3对T2D的因果相关性,在欧洲人群中复制.
结论:
- 在中国成年人的蛋白质组分析揭示了与T2D的新型蛋白质关联.
- 强有力的遗传证据支持了几种已识别的蛋白质在T2D中的因果作用.
- 这些蛋白质代表了T2D预防和治疗的有希望的新药标.
更多相关视频
09:52Generation of High Quality Chromatin Immunoprecipitation DNA Template for High-throughput Sequencing ChIP-seq
Published on: April 19, 2013
24.4K
03:39Author Spotlight: Multi-Layered Approach to Understand Postnatal Functions of Pancreatic Islets in Non-Human Primates
Published on: November 8, 2024
514
相关概念视频
Genome-wide Association Studies-GWAS
13.4K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
13.4K
Proteomics
7.3K
A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
7.3K
Diabetes Mellitus: Type 2 and Gestational
2.3K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.3K
Carbohydrate Metabolism
11.1K
Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
11.1K
