在患有双相情感障碍的患者中,皮层厚度或表面积与分歧思维之间的关联
Pei-Chi Tu1,2,3,4, Wan-Chen Chang1,2,5, Yi-Hsuan Kuan6
1Department of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan.
Acta neuropsychiatrica
|April 16, 2024
概括
不同思维能力在双相情感障碍 (BD) 患者和对照人群中是相似的. 然而,BD患者的大脑结构差异与创造性思维相关,特别是在右前额叶皮质.
科学领域:
- 神经科学是一个神经科学.
- 认知心理学 认知心理学
- 精神病学是一个精神病学.
背景情况:
- 不同思维是创造力的关键组成部分,在双相情感障碍 (BD) 中研究较少.
- 之前的研究探讨了健康个体的神经机制,但在BD患者中并不广泛.
- 众所周知,创造力和BD之间存在着联系,这促使进一步调查.
研究的目的:
- 为了研究双相情感障碍患者分歧思维的结构性大脑相关性.
- 为了比较BD患者和健康对照者的不同思维表现.
- 利用基于表面的形态测量来分析大脑结构差异.
主要方法:
- 招募了59名BD患者 (BD I/II) 和56名健康对照,根据年龄和性别进行匹配.
- 进行了中国版本的"成人缩写托伦斯测试" (ATTA),以评估分歧思维.
- 进行结构磁共振成像,并使用FreeSurfer 7.0.0分析皮质厚度和表面积.
主要成果:
- 在BD患者和对照人群之间没有观察到差异性思维表现的显著差异.
- 在BD患者中,分歧思维得分与右中前回,右叶和左前的皮质厚度相关.
- 与对照组不同的是,BD患者显示出分歧思维与右上额头的表面积之间的正相关性.
结论:
- 在BD患者中,分歧思维涉及执行控制,心理图像和视觉处理大脑区域.
- 右前额叶皮层似乎是双相情感障碍患者分歧思维的关键区域.
- 在BD中,结构性大脑差异与创造性认知过程有关.
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