无催化剂和无基可见光激活的基中继三甲基化/功能组迁移/碳化与CX3SO2Cl
Jinkai Hu1, Chenglei Yang1, Xiaotao Qin1
1State Key Laboratory of High-Efficiency Utilization of Coal and Green Chemical Engineering, College of Chemistry and Chemical Engineering, Analysis and Testing Center, Ningxia University, China. lidj2017@nxu.edu.cn.
Organic & biomolecular chemistry
|April 16, 2024
概括
一种新的可见光反应使得非和和酒精的激进三甲基化,蓝色迁移和碳基化成为可能. 这种高效的工艺避免了光催化剂,金属和基,提供了新的合成途径.
科学领域:
- 有机化学 有机化学
- 合成化学 合成化学
- 摄影化学的使用.
背景情况:
- 级联反应提供高效的合成途径,通过在单个操作中形成多个键.
- 可见光光还原催化已经成为可持续有机合成的强大工具.
- 开发用于非活性烯酸的1,2-双功能化的新方法仍然是一个重大挑战.
研究的目的:
- 开发一种新的可见光级联反应,用于合成功能化碳化合物.
- 在一个中实现三甲基化,蓝色迁移和碳化.
- 探索这种方法的应用到不同的基质,包括酒精.
主要方法:
- 一种由可见光辐射发起的激进级联反应.
- 使用CX3SO2Cl (X = F, Cl) 作为三甲基源.
- 在温和条件下进行反应,不需要光催化剂,过渡金属或基.
主要成果:
- 成功合成了从2-基-2--5-enenitrile中的5-oxo-2-(2,2,2-trihaloethyl) -pentanenitrile衍生物.
- 证明了 ([d]thiazol-2-yl) -pent-4-enol的转化为相应的4-([d]thiazol-2-yl) -6,6,6-三-六子产品.
- 反应系统对广泛的功能组表现出耐受性.
结论:
- 开发了一种新的,无金属,无基的可见光驱动级联反应.
- 该方法提供了一种高效和替代的方法,用于未激活的烯酸的1,2-双功能化.
- 该反应在温和条件下提供了一条实用的途径,以获得有价值的三甲基化碳化合物.
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