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关于Abrus precatorius叶中的潜在低血糖类黄类的研究:通过转录学和网络药理学的净化过程,质量概况和活性机制

Xujiang Yuan1, Xianmei Xue1, Zhike Liang1

  • 1Center for Drug Research and Development/Class III Laboratory of Modern Chinese Medicine Preparation, State Administration of Traditional Chinese Medicine of the P.R.C/ Key Laboratory of modern Chinese medicine of Education Department of Guangdong Province/Guangdong Provincial Key Laboratory of Advanced Drug Delivery Systems/ Guangdong Provincial Engineering Center of Topical Precise Drug Delivery System, Guangdong Pharmaceutical University, Guangzhou, P R China.

Natural product research
|April 16, 2024
PubMed
概括

来自Abrus precatorius叶 (APL) 的黄素通过调节关键目标和途径显示出有前途的低血糖效应. 这项研究支持开发高血糖的新疗法.

关键词:
APL,Abrus precatorius叶;HPLC,高性能液体染色学;T2D,2型糖尿病;AGE,先进的糖化终产物;LPS,脂多糖化;DPPH,2,2-二-1-皮克里;BV,床体积;DEGs,差异表达的基因;GO,基因本体学;KEGG,基因和基因组的京都百科全书.阿布鲁斯·普雷卡托里乌斯L L低血糖活动的低血糖.网络药理学 网络药理学净化 净化 净化 净化总的黄类化合物总量翻译学 翻译学 翻译学 翻译学

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α-glucosidase inhibitors, including acarbose (Precose), miglitol (Glyset), and voglibose (Voglib) (primarily available in Asia), are drugs that control blood sugar levels by delaying the digestion of starch and disaccharides. They achieve this by inhibiting α-glucosidase enzymes in the intestine, which slow the absorption of carbohydrates in the intestine, which in turn leads to a prolonged release of the glucoregulatory hormone GLP-1 from intestinal L-cells.
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