舌头涂层微生物和新陈代谢特征在炎
Y Zhang1,2,3,4,5,6, K L Lo1,2,3,4,5,6, A N Liman1,2,3,4,5,6
1Department of Preventive Dentistry, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Journal of dental research
|April 16, 2024
概括
炎与舌头涂层微生物和代谢物的显著变化有关. 这项研究确定了与口臭相关的特定微生物和代谢变化,为其原因提供了洞察力.
科学领域:
- 口腔微生物学 口腔微生物学
- 代谢学 代谢学 代谢学
- 化病研究研究 化病研究
背景情况:
- 鼻炎 (口臭) 对生活质量和社会互动产生负面影响.
- 舌头涂层微生物组与口臭的发展有关.
- 气味病中的动态微生物和代谢变异尚未完全理解.
研究的目的:
- 在有口臭但没有其他口腔疾病的个体中调查舌头涂层的微生物和代谢资料.
- 为了全面分析,利用元基因组学和代谢学.
- 识别关键的微生物和代谢特征,使口臭与健康状态有区别.
主要方法:
- 口腔检查和口臭评估.
- 采集舌头涂层样本,用于转基因组和代谢组分析.
- 使用机器学习分类器 (LASSO逻辑回归,随机森林) 进行多组学数据分析.
主要成果:
- 在口臭患者中增加了微生物的丰富性和多样性.
- 增加了Actinomyces,Prevotella,Veillonella和Solobacterium的丰富性;减少了Rothia和链球菌.
- 在口臭样本中,丰富的途径 (例如,囊和甲酸代谢) 和高代谢物 (英多-3-酸,鸟,L-酸) 在口臭样本中.
- 挥发性硫化合物和英多尔-3-酸水平之间的正相关性.
- 鉴定了19种物种和39种代谢物作为口臭的诊断特征.
结论:
- 舌头涂层微生物组和代谢组的显著变化是口臭的特征.
- 这些多原子变化表明在口臭发育中的潜在病因作用.
- 研究结果为了解口臭背后的机制提供了新的见解.
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