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从肠道衰竭到移植:回顾全球多学科移植计划下目前对移植指示的需求
Vikram K Raghu1, Carolina Rumbo2, Simon P Horslen1
1Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Pediatric transplantation
|April 16, 2024
概括
儿科肠道衰竭护理方面的进步,包括亲肠营养和肠移植,改善了生存率并减少了移植需求. 然而,有些孩子仍然需要移植以挽救生命的治疗或当亲肠道营养变得无法管理时.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 手术创新 在外科创新.
- 移植医学 移植医学
背景情况:
- 肠道衰竭 (IF) 显著挑战儿科护理,需要仔细考虑肠道移植.
- 管理IF需要先进的营养支持和手术干预.
- 肠子移植的时间是儿科IF管理中的关键决定.
研究的目的:
- 概述了小儿肠衰竭的历史发展和当前护理状况.
- 审查亲肠营养和肠移植在治疗IF中的作用.
- 讨论当代方法来治疗儿童肠道衰竭的治疗方法.
主要方法:
- 文献综述专注于作者临床经验.
- 对有关肠道衰竭管理的已公布数据的分析.
- 关于亲肠营养和肠移植的信息综合的演变.
主要成果:
- 亲肠营养 (PN) 和肠移植已经显著发展,家庭PN变得越来越普遍.
- 结肠炎的并发症往往决定需要进行肠道移植.
- 由于患者异质性,儿科IF的管理策略是复杂的,这会影响移植指示.
结论:
- 改进的医疗和外科护理提高了FI儿童的无移植生存率.
- 由于更好的管理,肠道移植的总体需求减少了.
- 肠子移植仍然是一个重要的,拯救生命的治疗选择儿科患者的IF或难治的PN依赖.
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