来自Piper kadsura (选择性) Ohwiwi的具有抗炎活性的新木素
Xingxing Liu1, Yi Wen1, Xilei Wang1
1Department of Pharmacy, Zhongnan Hospital of Wuhan University, School of Pharmaceutical Sciences, Wuhan University, Wuhan, China.
Natural product research
|April 16, 2024
概括
在Piper kadsura树干中发现了两种新的新. 一些化合物通过抑制细胞中氧化 (NO) 生产显示出抗炎作用.
科学领域:
- 自然产品化学 自然产品化学
- 药理学 药理学是指药理学的学科.
背景情况:
- Piper kadsura 的茎是生物活性化合物的来源.
- 新木质物和木质物是具有多种生物活动的自然产品类别.
研究的目的:
- 从Piper kadsura中分离和描述新的新木头人.
- 评估隔离化合物的体外抗炎潜力.
主要方法:
- 使用光谱数据和ECD计算,对化合物的隔离和结构阐明.
- 在体外抗炎测定测量氧化物 (NO) 生产抑制在脂多糖 (LPS) 刺激的RAW 264.7细胞.
主要成果:
- 发现了两种新型新质素,即 piperkadsurenin A (1) 和 kadsurenin N (2).
- 化合物1是第一个报告的新木质与环[b]pyran框架.
- 化合物3和7显著抑制了NO生产,其IC50值分别为34.29 ± 0.82 μM和47.5 ± 5.81 μM.
结论:
- Piper kadsura 是一种新的新木结构的宝贵来源.
- 一些孤立的新素和素具有显著的抗炎性质.
- 对这些化合物的进一步研究可能会导致新的治疗剂.
更多相关视频
04:30Quantifying the Modulation of Elastase Enzyme Activity Through Colorimetric Analysis
Published on: January 17, 2025
988
11:44Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B
Published on: January 19, 2022
2.5K
相关概念视频
01:19Antiasthma Drugs: Leukotriene Modifiers
282
Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
Leukotriene modifiers work through two distinct mechanisms:
Leukotriene modifiers work through two distinct mechanisms:
282
01:20Drugs for Peptic Ulcer Disease: Prostaglandin Analogs as Mucosal Protective Agents
423
The gastric mucosa produces prostaglandins E2 (PGE2) and prostacyclin (PGI2), crucial in maintaining gastric health. They exert cytoprotective effects, including increasing bicarbonate secretion, releasing protective mucin, reducing gastric acid output, and preventing harmful vasoconstriction. These effects are mediated through various receptors, such as EP1, EP2, EP3, and EP4.
Non-steroidal anti-inflammatory drugs (NSAIDs) can induce peptic ulcers by inhibiting cyclooxygenase, decreasing...
Non-steroidal anti-inflammatory drugs (NSAIDs) can induce peptic ulcers by inhibiting cyclooxygenase, decreasing...
423