牙周炎,牙科手术和年轻发病的密码性中风
J Leskelä1, J Putaala2, N Martinez-Majander2
1Department of Oral and Maxillofacial Diseases, University of Helsinki, Helsinki, Finland.
Journal of dental research
|April 16, 2024
概括
牙周炎显著增加了年轻成年人密码性缺血性中风 (CIS) 的风险. 最近的侵袭性牙科手术也增加了CIS风险,特别是在那些有 patent foramen ovale.
科学领域:
- 神经学 神经学
- 牙周病学 牙周病学
- 公共卫生 公共卫生
背景情况:
- 牙周炎是已知的缺血性中风风险因素.
- 在年轻成年人中,牙周炎和密码性缺血性中风 (CIS) 之间的关联需要进一步研究.
研究的目的:
- 检查牙周炎,最近的侵袭性牙科治疗和年轻开始的CIS之间的关联.
- 探索血清生物标志物和卵孔 (PFO) 在这种协会中的作用.
主要方法:
- 一个多中心病例控制研究 (SECRETO) 涉及146例病例控制对的CIS患者和18-49岁的对照.
- 临床和放射性口腔检查,血清脂多糖 (LPS) 和脂多酸 (LTA) 测量.
- 多变量条件回归模型根据中风风险因素,牙医访问和PFO状态进行调整.
主要成果:
- 牙周炎在CIS患者中被诊断为27.5%,对照组为20.1% (P < 0.001).
- CIS与较高的牙周炎症 (OR 10.48) 和严重的牙周炎 (OR 7.48) 有着强烈的关联.
- 在中风前3个月内进行的侵袭性牙科治疗显示,CIS的OR为2.54,PFO的OR显著更高 (OR6.26).
结论:
- 牙周炎和最近的侵入性牙科手术是年轻发病CIS的重要危险因素.
- 脑卒中的严重程度与牙周炎的严重程度相关.
- 细菌病 (LPS/LTA) 似乎没有介导观察到的风险.
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