结肠直肠癌干细胞生物标志物:生物学特征和预后见解

相关实验视频

Updated: Jun 28, 2025

06:52

Discovery of Driver Genes in Colorectal HT29-derived Cancer Stem-Like Tumorspheres

Published on: July 22, 2020

6.5K

Atena Soleimani¹, Nikoo Saeedi², Abdulridha Mohammed Al-Asady³

¹Department of Biochemistry, Mashhad University of Medical Sciences, Razavi Khorasan, Mashhad, Iran.

Current pharmaceutical design

|April 16, 2024

概括

癌症干细胞 (CSCs) 驱动瘤的发展,并通过特定的标记物来识别. 本综述分析了关键的结直肠CSC标志物 (LGR5,ALDH,CD166,CD133,CD44) 以改善CRC诊断和治疗.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
生物标志物研究生物标志物研究

背景情况:

癌症干细胞 (CSCs) 具有自我更新和增殖能力,有助于瘤的开始和进展.
细胞瘤由细胞表面标记物识别,这些标记物对于理解瘤生物学和开发向疗法至关重要.
结肠直肠癌 (CRC) 的诊断和预后可以通过CSC及其相关生物标志物的治疗应用来提高.

研究的目的:

对包括LGR5,ALDH,CD166,CD133和CD44在内的特定结直肠CSC标记物进行综合性审查.
在结肠直肠癌病原和临床结果的背景下分析这些选定的标记物的功能.
在CRC内提供对CSC生物学的新见解,以告知未来的研究和治疗策略.

主要方法:

文献综述侧重于已确立的结直肠CSC标记物.
在CRC中分析LGR5,ALDH,CD166,CD133和CD44的意义.
综合有关CSC标记函数及其在CRC中的作用的信息.

主要成果:

确定一组关键结直肠CSC标记物 (LGR5,ALDH,CD166,CD133,CD44) 的小组,这些标记物在CRC中起着重要作用.
详细分析这些标记物在CRC病变发生过程中的功能意义.
突出这些标记物的潜力,用于针对性诊断和治疗方法在CRC.

结论:

分析的结直肠CSC标志物对于理解CRC生物学和进展至关重要.
这些标记物具有显著的潜力,可以提高结肠直肠癌的诊断准确性和治疗疗效.
对这些CSC标记物的进一步研究对于开发CRC的先进治疗策略至关重要.

关键词:

据报道,阿尔德 (ALDH) 已经开始.CD133 是一个CD133 CD133 是一个CD133 CD166 是一个CD166 是一个CD166 在CD4444中,我们可以看到CD44.在LGR5中,LGR5是指LGR5.癌症干细胞是一种癌症干细胞.大肠癌.结肠癌.

相关概念视频

02:40

Cancer Stem Cells and Tumor Maintenance

4.9K

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...

4.9K

01:18

Distinctive Features of Adult Stem Cells vs Cancer Stem Cells

3.5K

A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...

3.5K

02:07

Tumor Progression

6.3K

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...

6.3K

01:12

Role Of Notch Signalling In Intestinal Stem Cell Renewal

2.1K

Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...