心脏衰老的性别相关差异:临床方面和分子机制
Margarita Calvo-López1, Luis Ortega-Paz2, Francisco Rafael Jimenez-Trinidad3,4
1Clínic's Cardiovascular Institute (ICCV), Hospital Clinic of Barcelona, Barcelona, Spain.
European journal of clinical investigation
|April 16, 2024
概括
心血管疾病 (CVD) 是老年人死亡的主要原因. 本综述探讨了衰老和性别如何影响心血管疾病,重点关注更好的预防和治疗的分子机制.
科学领域:
- 老年学是指老年学的学科.
- 心脏病学 心脏病学
- 分子生物学分子生物学
背景情况:
- 心血管疾病 (CVD) 是65岁及以上人群死亡的主要原因,超过了癌症.
- 年龄是心血管衰老的独立风险因素,影响心脏和血管功能.
- 全球人口老龄化,使老年人心血管疾病的患病率和负担增加.
研究的目的:
- 审查当前对心血管衰老的科学理解.
- 探索性对心血管疾病发病和进展的影响.
- 确定心血管衰老背后的分子机制及其临床影响.
主要方法:
- 关于心血管衰老和心血管疾病的性别差异现有科学文献的综述.
- 专注于结构性,荷尔蒙性,遗传性/表观遗传性和炎症途径.
- 分析与心血管衰老相关的分子机制.
主要成果:
- 性行为显著影响心血管疾病的发病和严重程度,女性经历较晚的发病和非典型症状.
- 绝经后,女性心血管疾病的发病率和严重程度增加,与男性相等.
- 心血管衰老的分子机制及其临床相关性需要进一步详细研究.
结论:
- 了解心血管衰老中的性别差异对于定制的预防和治疗策略至关重要.
- 对分子通路的进一步研究可以提高老年人心血管疾病的诊断,预后和管理.
- 将心血管衰老的发现转化为临床实践对于改善患者的治疗结果至关重要.
相关概念视频
01:26Aging
49
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
49
01:29Pathophysiology of Cardiac Performance
645
Typical heart performance is influenced by heart rate, rhythm, myocardial contraction, and metabolism or blood flow. The cardiac muscle exhibits distinct electrophysiological features, including pacemaker activity and calcium channel control, which play a vital role in the heart's response to various drugs. The autonomic nervous system, comprising the sympathetic and parasympathetic branches, regulates heart rate. Sympathetic activation increases heart rate, while parasympathetic activation...
645