吸烟的进展和尼古丁增强的奖励灵敏度预测的休息状态功能连接在突出和执行控制网络
Matthew P Gunn1, Gregory M Rose2, Alexis E Whitton3,4
1Department of Psychology, Southern Illinois University, Carbondale, IL, USA.
概括
年轻吸烟者的大脑连接差异预测了尼古丁增强的奖励敏感性和吸烟进展. 较弱的突出网络功能连接与吸烟风险增加有关.
科学领域:
- 神经科学是一个神经科学.
- 成研究 研究成研究
- 神经成像是一种神经成像.
背景情况:
- 尼古丁增强奖励敏感性 (NERS) 和吸烟进展的个体差异尚不清楚.
- 需要进行研究,以了解年轻轻吸烟者的这些差异的神经基础.
研究的目的:
- 调查尼古丁戒断期间的静止状态功能连接 (rsFC) 是否预测NERS和吸烟进展.
- 假设特定大脑区域 (岛屿,ACC,海马,丘脑,NAcc,PFC) 之间的高rsFC将预测NERS和吸烟的进展.
主要方法:
- 64名轻度吸烟的年轻人 (18-24岁),每周吸5-35支香烟,经过14小时的尼古丁剥夺后接受了fMRI.
- 参与者完成了一个概率奖励任务后安慰剂和定期的香烟管理在不同的日子.
主要成果:
- 较大的NERS与右前PFC和右NAcc之间增加的rsFC相关.
- 观察到ACC和左下额前环之间,以及insula和ACC之间的rsFC减少.
- 在突出网络 (ACC和insula) 中减少rsFC预测了18个月的吸烟进展增加和更大的NERS.
结论:
- 首次证据将年轻轻烟民的rsFC差异与NERS和吸烟进展联系起来.
- 较弱的突出网络rsFC预测了更大的NERS和吸烟进展.
- 突出网络rsFC和药物增强奖励灵敏性可能成为成研究的潜在内分类型.
更多相关视频
08:47Spectral Confocal Imaging of Fluorescently tagged Nicotinic Receptors in Knock-in Mice with Chronic Nicotine Administration
Published on: February 10, 2012
13.5K
10:04Local Application of Drugs to Study Nicotinic Acetylcholine Receptor Function in Mouse Brain Slices
Published on: October 29, 2012
19.2K
相关概念视频
01:29Stimulants
192
Stimulants are substances that enhance neural activity and elevate dopamine levels in the brain, leading to their highly addictive nature. These drugs include cocaine, amphetamines, MDMA, caffeine, and nicotine, each with distinct mechanisms of action and varied health implications.
Cocaine can be administered via snorting, injection, or smoking. It primarily functions by blocking the reuptake of dopamine, resulting in a euphoric high characterized by an intense sensation of happiness and...
Cocaine can be administered via snorting, injection, or smoking. It primarily functions by blocking the reuptake of dopamine, resulting in a euphoric high characterized by an intense sensation of happiness and...
192
01:27CNS Depressants: Alcohol and Nicotine
205
Ethanol, a clear colorless alcohol, has been consumed by humans for millennia, but its effects on the body are far from benign. At lower doses, it induces decreased inhibitions and loquaciousness, leading to its social appeal. However, it can cause severe consequences at higher doses, such as coma and respiratory depression, due to its zero-order elimination kinetics. Chronic ethanol abuse wreaks havoc on multiple organ systems, particularly the CNS and the liver. Abrupt cessation of ethanol...
205