暴露于质子抑制剂的儿童的长度微生物组变化
Yanjia Jason Zhang1,2, Sarah Connearney1, Lisa Hester1
1Gastroenterology/Nutrition, Boston Children's Hospital, Boston, Massachusetts, USA.
Clinical and translational gastroenterology
|April 16, 2024
概括
质子抑制剂 (PPI) 的使用改变了儿童的肠道微生物组,增加了菌和口细菌在便中. 这项研究跟踪了儿科患者在PPI治疗前后的微生物组变化.
科学领域:
- 微生物学 微生物学
- 儿科胃肠病学 儿科胃肠病学
- 微生物组研究 微生物组研究
背景情况:
- 质子抑制剂 (PPI) 与儿童感染有关.
- 关于儿童群体中PPI影响的纵向数据有限.
- 了解PPI诱导的微生物组变化对于儿科健康至关重要.
研究的目的:
- 为了前性地比较儿童在开始PPI治疗之前和之后的便和口腔肠微生物组.
- 为了确定受儿童PPI使用影响的特定微生物种群.
- 调查与年龄相关的敏感性,以PPI诱导的微生物组变化.
主要方法:
- 预期的观察性研究设计.
- 从一个儿科胃肠病学诊所招聘.
- 在基线和PPI启动后8周收集便和口腔便样本.
- 用于微生物组分析的16S rRNA基因测序.
主要成果:
- 在便或口腔喉中,整体微生物群落结构 (β-多样性) 没有显著变化.
- 特定细菌种群的显著变化,包括便中的链球菌的丰富.
- 在便中减少Bifidobacterium,Peptostreptococcus和Turicibacter的相对丰度.
- 在PPI治疗后的便样本中增加了口腔菌的相对丰度,特别是在年幼的儿童中.
结论:
- 尽管整体多样性没有变化,但PPI治疗显著改变了儿科微生物组合.
- 便中的口细菌的丰富表明了改变微生物转移或殖民的可能性.
- 年龄较小的儿童似乎更容易受到PPI诱导的微生物组改变,因此需要进一步调查临床和微生物因素.
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