通过对人类表皮生长因子受体2进行下调来探索药用植物对抗乳腺癌的抗癌特性
Sunny Gupta1, Rashima Prem2, Chinmayee Sethy1
1Kusuma School of Biological Sciences, Indian Institute of Technology Delhi, New Delhi 110016, India.
Journal of agricultural and food chemistry
|April 16, 2024
概括
药用植物提取物对抗HER2阳性乳腺癌具有抗癌作用. 一些植物,包括Terminalia chebula,Berberis aristata和Mucuna pruriens,显著降低HER2表达并调节细胞死亡途径.
科学领域:
- 植物化学 植物化学
- 在瘤学瘤学.
- 分子生物学分子生物学
背景情况:
- 传统医学利用植物来治疗癌症.
- 缺乏植物性减少乳腺癌中HER2表达的科学证据.
- HER2阳性乳腺癌需要有针对性的治疗策略.
研究的目的:
- 评估10种药用植物提取物对HER2阳性乳腺癌细胞的抗癌特性.
- 研究这些提取物对HER2表达水平的影响.
- 为了确定 HER2 阳性乳腺癌的药用植物潜在的新型治疗剂.
主要方法:
- 使用SRB测定对10种药用植物提取物的抗增殖活性进行选.
- 通过彗星测定和使用附件V-FITC染色诱导亡来评估DNA损伤.
- 通过免疫阻塞对HER2表达水平的评估.
- 关键植物提取物和治疗癌细胞的蛋白质和代谢分析.
主要成果:
- 所有测试的植物提取物都对HER2阳性乳腺癌细胞表现出抗增殖作用.
- ,Berberis aristata和Mucuna pruriens显著降低了HER2的表达.
- 治疗导致Bax/Bcl-2比率增加,这表明诱导了亡.
- 蛋白质组分析显示,在使用选定的植物提取物治疗后,蛋白质表达特征发生了显著的变化.
结论:
- 药用植物对HER2阳性乳腺癌具有显著的抗癌潜力.
- 特定的植物提取物,特别是T. chebula,B. aristata和M. pruriens,表现出有希望的HER2降低调节特性.
- 这些发现支持植物衍生化合物的发展,作为HER2阳性乳腺癌的新疗法选择.
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