概述冠状病毒COVID-19及其病原和疾病风险评估,利用临床和实验室数据的积极预测值
Tapan Krishna Biswas1, Malabika Biswas2, Rajib Bandyopadhyay1
1Department of Instrumentation and Electronics Engineering, Jadavpur University, Kolkata, India.
概括
COVID-19通过将铁与血红蛋白分离而破坏氧气交换,导致肺损伤和凝血. 临床数据和生物标志物可以在RT-PCR结果可用之前评估COVID-19风险.
科学领域:
- 生物化学 生化学
- 病理学 病理学 病理学
- 病毒学 病毒学
背景情况:
- COVID-19大流行影响全球健康,导致严重的呼吸困难和凝血障碍.
- 在SARS-CoV-2病毒干扰血红蛋白的血红蛋白结构,损害氧气和二氧化碳的运输.
- 铁离子和二氧化碳的增加有助于肺部损伤和疾病的严重程度.
研究的目的:
- 研究COVID-19引起的肺损伤和凝血的生物化学机制.
- 确定用于早期COVID-19风险评估的关键临床和生物化学参数.
- 在RT-PCR确认之前建立COVID-19的风险评估工具.
主要方法:
- 对病毒对血红蛋白和铁离子解离的影响的分析.
- 血清生物标志物的监测,包括费里丁,LDH,d-二次体,IL-6和心脏素.
- 评估临床数据,如年龄,发烧,性别和并发症.
主要成果:
- COVID-19导致铁离子与海姆离合,阻碍了气体交换.
- 观察到血清费里丁,LDH,d-二次体,IL-6和素的增加.
- 白血细胞症,淋巴细胞衰减和肺部放射性变化是病理的标志.
结论:
- 血红蛋白的生物化学破坏是COVID-19病变发生的关键机制.
- 临床和生化标志物可以作为COVID-19早期风险评估工具.
- 及时的风险评估可以指导干预,并可能挽救生命.
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