怀孕期间母亲的禁食葡萄糖水平与学龄前儿童的折射误差之间的关联
Yufan Guo1, Jixing Zhou1, Jingru Lu1
1Department of Maternal, Child & Adolescent Health, School of Public Health, Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Anhui Provincial Key Laboratory of Population Health and Aristogenics, Anhui Medical University, Ministry of Education of the People's Republic of China, No. 81 Meishan Road, Hefei, 230032, Anhui, China.
The Journal of clinical endocrinology and metabolism
|April 16, 2024
概括
怀孕期间母亲的高禁食血葡萄糖 (FPG) 轨迹与6岁儿童中折射误差,超视度和形的风险增加有关. 怀孕早期的葡萄糖水平似乎对视觉发育至关重要.
科学领域:
- 眼科医生 眼科 眼科
- 孕产妇和胎儿医学 孕产妇和胎儿医学
- 发育儿科 发育儿科
背景情况:
- 怀孕期间母亲的健康显著影响后代的长期健康结果.
- 孕期葡萄糖代谢是胎儿发育的关键因素.
- 了解母亲葡萄糖对孩子视力的影响对于早期干预至关重要.
研究的目的:
- 研究怀孕期间母亲的空腹血葡萄糖 (FPG) 轨迹与6岁儿童的折射误差之间的关联.
- 在怀孕期间确定关键窗口,其中母亲的葡萄糖水平可能会影响儿童的视觉发育.
主要方法:
- 在Ma'anshan出生队列 (MABC) 研究中利用了1987年母婴对的数据.
- 采用基于小组的轨迹建模来定义跨季度的孕产妇FPG模式.
- 在6岁时使用标准眼科检查评估儿童的折射误差和视力敏度,并分析了与逻辑回归和GEE模型的关联.
主要成果:
- 具有高FPG轨迹的母亲在6岁时生育的孩子具有明显更高的折射误差 (OR=1.46),超视度 (OR=1.64),和纹 (OR=1.60) 的风险.
- 第一个和第二个三个月的母体葡萄糖水平与儿童远视值有负相关性.
- 怀孕期间特定的FPG轨迹与儿童早期常见视力障碍的几率增加有关.
结论:
- 怀孕期间母亲FPG轨迹的升高与6岁儿童中折射误差,超视度和的患病率增加有关.
- 怀孕的第一和第二个三个月代表了母亲葡萄糖代谢可能影响胎儿眼睛发育的关键时期.
- 需要进一步的研究,以探索母亲的葡萄糖代谢对儿童视觉发育的长期影响,并为潜在的预防策略提供信息.
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