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生物制造指导在总结免疫系统在芯片上的方向

Robine Janssen¹, Laura Benito-Zarza¹, Pim Cleijpool¹

¹Department of Pharmaceutical Sciences, Pharmacology, Utrecht University, Utrecht, 3584 CG, The Netherlands.

Advanced healthcare materials

|April 16, 2024

概括

这篇评论探讨了免疫器官芯片 (OoC) 模型,突出了生物制造.

科学领域:

生物医学工程生物医学工程
免疫学免疫学免疫学
微流体学微流体学

背景情况:

微流体学已经推进了体外模型,创造了复杂的芯片器官 (OoC).
OoCs通过 perfusion 和刺激模仿生理环境.
将免疫成分集成到OOC中对于人类生理学表示至关重要.

研究的目的:

审查免疫OOC模型的最新情况.
突出生物制造在免疫OOC发展中的作用.
探索免疫细胞在微流体系统中的行为和反应.

主要方法:

对免疫OOC模型的综合文献综述.
对免疫OOC平台的生物制造技术的分析.
探索免疫细胞的行为,交叉声和微流体环境中的反应.

主要成果:

生物制造是实现免疫OoCs生理相关性的关键.
模仿免疫细胞行为和相互作用是必不可少的.
确定了免疫OOC生物制造当前的挑战和突破.

结论:

免疫OoC模型正在推动对免疫生理学的理解.
生物制造技术对于开发准确,预测性免疫OOC模型至关重要.
这些模型对研究免疫相关疾病和免疫调节有前途.

关键词:

通过3D打印打印3D打印.生物制造是生物制造的方法.免疫细胞免疫细胞免疫器官免疫器官免疫反应的免疫反应.免疫系统免疫系统微流体学在微流体学方面器官在芯片上的器官

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