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利津通过调节肠道微生物群组成,限制了小鼠的牛病毒性腹病毒感染

Zhicheng Zhao^1,2,3, Chuang Li^1,2,3, Jiang Huang^1,4

¹College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing 163319, China.

Journal of agricultural and food chemistry

|April 16, 2024

概括

化 (PHZ) 通过恢复T细胞和增强肠道微生物群来保护小鼠免受牛病毒性腹病毒 (BVDV) 的感染. 来自PHZ治疗小鼠的便微生物群移植减少了病毒载量和病变,突出显示了肠道微生物群.

科学领域:

病毒学病毒学
免疫学免疫学免疫学
微生物组研究微生物组研究

背景情况:

利津 (PHZ),是Lithocarpus polystachyus中的活性化合物,已经证明了抗病毒性质.
之前的研究表明PHZ抑制牛病毒性腹病毒 (BVDV) 复制,但其体内机制尚不清楚.
在动物健康方面,BVDV感染带来了重大挑战,需要新的治疗策略.

研究的目的:

阐明PHZ对BVDV的体内抗病毒机制.
研究PHZ对宿主免疫反应和肠道微生物群的影响.
评估肠道微生物群调节在PHZ抗病毒功效中的潜力.

主要方法:

用PHZ治疗BVDV感染的小鼠,并分析免疫细胞群 (CD3 +,CD4 +,CD8 + T细胞).
使用元基因组测序来评估肠道微生物组成和多样性的变化.
从接受PHZ治疗的捐赠者到接受者小鼠进行了便微生物群移植 (FMT),以评估抗病毒效应的功能转移.

主要成果:

在BVDV感染的小鼠中,PHZ治疗显著恢复了CD3+,CD4+和CD8+T细胞的百分比.
PHZ显著增加了肠道微生物群的丰富性,多样性和有益的SCFA生产细菌的丰富性.
PHZ-FMT显著降低了BVDV负载,并改善了接受者小鼠的十二指肠和阴中的病理病变.

结论:

肠道微生物群在调解PHZ对BVDV的抗病毒活性方面发挥着至关重要的作用.
PHZ调节肠道微生物群,有助于其保护作用.
有针对性的肠道微生物群干预措施代表了BVDV预防和控制的潜在内源性策略.

关键词:

牛病毒性腹病毒病毒便微生物群移植我们的肠道微生物群.弗洛里津是一种化剂.

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