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Updated: Jun 28, 2025

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通过定制的超可塑性载体来增加细菌性伤口并发症的双重药物输送

Kanika Arora1, Bharti Dhruw1, Sherilraj Pm1

  • 1Infectious Disease Biology Laboratory, Chemical Biology Unit, Institute of Nano Science & Technology, Sector 81, Mohali, Punjab 140306, India.

Bioconjugate chemistry
|April 16, 2024
PubMed
概括

装有银硫法和维生素E的先进脂质纳米颗粒加速受感染的伤口愈合. 这种新的方法显示了副作用的减少和显著的细菌减少,为皮肤损伤提供了一个有前途的治疗策略.

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Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
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Drug Delivery: Enteral Route

The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
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Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
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