传染病对生物医学设备和材料的影响
Matthew M Brigmon1, Robin L Brigmon2
1Department of Infectious Diseases and Pulmonary Critical Care, Long School of Medicine, UT Health San Antonio, San Antonio, USA.
Biomedical materials & devices (New York, N.Y.)
|April 16, 2024
概括
由于抗生素耐药性,生物医学设备感染是一个日益严重的问题. 这项研究回顾了挑战,病原体和新型纳米结构材料,以预防和治疗这些感染.
科学领域:
- 生物材料科学 生物材料科学
- 传染性疾病 传染性疾病
- 纳米技术 纳米技术
背景情况:
- 传染病和医院感染在医疗保健中带来了重大挑战,特别是在生物医学材料和设备方面.
- 当前的聚合物材料往往无法抵抗微生物生长,加剧了生物医学植入物的问题.
- 微生物抗生素耐药性的增加使得与医疗器械相关的感染的管理变得复杂.
研究的目的:
- 审查诊断设备相关感染的挑战及其对抗生素耐药性的贡献.
- 概念化设备相关感染的发病过程,重点关注生物膜形成和宿主免疫反应.
- 探索当前和未来的预防策略,治疗选择,以及用于植入器件的抗微生物纳米结构材料的开发.
主要方法:
- 关于设备相关感染病原,诊断和治疗的文献综述.
- 生物膜形成和宿主免疫/抗菌疗法的相互作用的概念化.
- 分析当前和正在发展的预防策略和新的治疗方法.
- 对纳米结构抗微生物材料的潜在制造方法的审查.
主要成果:
- 难以诊断与设备相关的感染有助于增加微生物抗生素耐药性.
- 生物膜形成是设备相关感染的关键因素,涉及宿主免疫和抗菌疗法.
- 目前和新兴的战略旨在预防与生物医学设备相关的传染病.
- 开发具有抗微生物功能的纳米结构材料用于植入式设备是一个有前途的领域.
结论:
- 需要改进治疗策略以应对日益增长的抗菌素耐药性.
- 新型纳米结构材料在可植入器件中提供了增强抗菌功能的潜力.
- 结合预防和新型治疗的综合方法对于改善生物医学设备护理至关重要.
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