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加多对巨细胞的保留效应 - - 可能是MRI对比剂Dotarem毒性的潜在原因

Marta Halasa^1,2, Ahmed Uosef^1,2, Henry V Ubelaker^1,2

¹Transplant Immunology, The Houston Methodist Research Institute, 6670 Bertner Ave., Houston, TX, 77030, USA.

Cell and tissue research

|April 16, 2024

概括

来自MRI对比剂的加多积聚在巨细胞中,损害免疫细胞的功能. 长期保留加多会显著降低巨细胞的运动性,并改变关键的免疫和纤维化通路,可能会伤害患者.

科学领域:

免疫学免疫学免疫学
毒理学毒理学毒理学
生物医学成像技术生物医学成像技术

背景情况:

像Dotarem这样的基于加多的对比剂 (GBCA) 在MRI中被广泛使用.
加多会积聚在器官和组织中,具有潜在的长期毒性作用.
之前的研究表明,在暴露后至少7天内,加多在巨细胞中被保留.

研究的目的:

调查加多保留对巨细胞功能和分子通路的影响.
评估1天和7天的加多暴露对巨细胞行为的影响.

主要方法:

巨细胞培养暴露于加多1天和7天.
对巨细胞粘附,运动,蛋白质表达和mRNA转录的分析.
专注于与粘附,纤维化和免疫反应相关的蛋白质和基因.

主要成果:

七天的加多保留显著降低了巨细胞的粘附和运动性.
蛋白质 (Notch1, Jagged1, PAK1, Shp1, Smad3, TCF19) 和化基因 (CXCL10,CXCL13) 的失调表达.
纤维化基因 (Col6a1,Fibronectin,MMP9,MMP12) 的改变mRNA表达和完全抑制M2标记物Arg-1.

结论:

巨细胞中加多的保留破坏了关键的细胞功能和分子通路.
观察到的变化可能会对患者的免疫系统和反应产生负面影响.
需要进一步的研究来了解加多诱导的巨细胞功能障碍的临床影响.

关键词:

凝聚力凝聚力凝聚力达特雷姆的目的是为了让他们.纤维化纤维化纤维化在加多利尼姆 (Gadolinium) 中.在MRI对比图像中,MRI对比图像是相反的.巨细胞是一个巨细胞.运动运动运动

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