在英国生物银行中,老年大脑中的大脑结构共存
Chao Dong1, Anbupalam Thalamuthu2, Jiyang Jiang2
1Centre for Healthy Brain Ageing (CHeBA), Discipline of Psychiatry and Mental Health, School of Clinical Medicine, UNSW, Sydney, Australia. chao.dong1@unsw.edu.au.
随着年龄的增长,大脑结构发生变化,区域之间的相关性发生变化. 这些变化影响了认知,大多数区域协会不同于与年龄相关的模式.
科学领域:
- 神经成像是一种神经成像.
- 老龄化大脑研究研究
- 结构共变性分析
背景情况:
- 大脑区域的形态特性表现出共同变异.
- 了解与年龄相关的大脑结构的变化对于认知健康至关重要.
研究的目的:
- 调查老年大脑皮层厚度和皮层下体积的结构共变性.
- 检查结构共变性,年龄和认知之间的关联.
- 分析大脑结构共变性模式的年龄组差异.
主要方法:
- 利用来自英国生物库的横截面数据 (N=42,075,年龄在45-83岁之间).
- 将参与者分为84个不重叠的年龄组进行分析.
- 检查了84个皮层厚度和皮层下共差,评估年龄和认知关联.
主要成果:
- 在衰老过程中观察到结构协同变异的显著差异,包括变异的增加和的减少.
- 在所有年龄组的头叶内对对相关性中发现了丰富.
- 在62个皮层厚度和10个皮层下体积相关性中确定了显著的年龄关联,具有不同的趋势 (增强,减弱,逆转).
- 指出,大多数与认知相关的相关性显示出与年龄相关模式相反的趋势.
结论:
- 老化大脑中的结构共变性模式随着年龄的增长表现出显著的变化和变化,特别是在64岁之后.
- 与年龄相关的结构共变性改变与认知衰退有关,相关性趋势不同.
- 这些发现凸显了整个衰老过程中大脑结构关系的动态性质.
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