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Updated: Jun 28, 2025

Assessment of Selective mRNA Translation in Mammalian Cells by Polysome Profiling
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Published on: October 28, 2014

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减弱核糖体负载通过限制转化依赖的mRNA衰变来改善mRNA的蛋白质输出

Alicia A Bicknell1, David W Reid1, Marissa C Licata1

  • 1Moderna, Inc, 325 Binney Street, Cambridge, MA 02142, USA.

Cell reports
|April 16, 2024
PubMed
概括

优化信使RNA (mRNA) 治疗方法需要仔细设计编码序列 (CDS). 减弱,而不是最大化,核糖体负载可以提高mRNA稳定性和蛋白质输出,以获得更好的治疗疗效.

关键词:
科普:分子生物学 分子生物学在mRNA衰变过程中.在mRNA治疗中,mRNA疗法.核糖体的核糖体是指核糖体中的核糖体.翻译翻译翻译翻译翻译翻译

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