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多微生物血流感染是新生儿死亡的风险因素在国家医院,坦桑尼亚:一个病例对照研究研究

Joel Manyahi¹, Agricola Joachim¹, Frank Msafiri¹

¹Department of Microbiology and Immunology, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.

|April 16, 2024

概括

多微生物血流感染 (BSI) 与单微生物BSI相比,显著增加死亡风险. 积极的管理对于更好的患者结果和减少住院时间至关重要.

科学领域:

传染性疾病传染性疾病
临床微生物学临床微生物学
公共卫生公共卫生

背景情况:

多微生物血流感染 (BSI) 由于实证抗生素对多种病原体的有效性降低,因此存在治疗挑战.
了解多微生物与单微生物BSI的比较结果对于优化患者护理至关重要.

研究的目的:

为了比较诊断出多微生物BSI和单微生物BSI的患者之间的临床结果.
确定与BSI患者死亡相关的独立风险因素.

主要方法:

从2021年7月到2022年6月,在穆希姆比利国家医院进行了一项回顾性病例控制研究.
患有多微生物BSI的患者 (病例) 与基于年龄,病房和入院时间的三组单微生物BSI的对照进行了匹配.
使用后勤回归分析来确定住院和30天死亡率的独立风险因素.

主要成果:

多微生物BSI与增加的住院死亡率 (aOR 2.37) 和30天死亡率 (aOR 2.05) 独立相关.
在新生儿中,多微生物BSI是医院住院 (aOR 5.08) 和30天死亡率 (aOR 3.13) 的重要风险因素.
隔离物经常表现出多重药物耐药性 (52%),多微生物BSI患者在数量上住院时间更长.

结论:

多微生物BSI是死亡率的重要独立风险因素.
与单微生物BSI患者相比,患有多微生物BSI的患者在医院住院时间较长.
临床医生应该采取一个更积极的管理策略,对多微生物BSI.

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