评估美国少数群体中心房动的确定偏差
Lars Hulstaert1, Amelia Boehme2, Kaitlin Hood3
1R&D Data Science & Digital Health, Janssen-Cilag GmbH, Neuss, North Rhine-Westphalia, Germany.
PloS one
|April 16, 2024
概括
这项研究揭示了美国少数群体中较低心房动 (AF) 的患病率. 鉴定偏差显著影响这些AF流行率估计,特别是在亚洲和西班牙裔或拉丁裔人口中.
科学领域:
- 心脏病学 心脏病学
- 公共卫生 公共卫生
- 健康差异 在健康上的差异
背景情况:
- 心房动 (AF) 是一种常见的心律失常,对健康有重大影响.
- 现有的数据表明,美国不同种族和族裔群体的AF患病率存在差异.
- 了解这些差异对于公平的医疗保健和临床试验招生至关重要.
研究的目的:
- 确定美国少数群体中心房动 (AF) 的流行率和发病率.
- 评估确定偏差对不同人群中AF患病率估计的影响.
- 为AF研究中的临床试验提供多样性招生目标的信息.
主要方法:
- 一项队列研究分析了来自Optum的Clinformatics® Data Mart数据库 (2017-2020) 的非识别数据.
- 从住院和门诊索赔中使用经过验证的ICD-10-CM诊断算法确定了心房动 (AF) 的存在.
- 发病率和发病率为总人口和最近发生中风事件的子组计算.
主要成果:
- AF的周期性流行率为4.9% (黑人),3.2% (亚洲人),2.1% (西班牙裔/拉丁裔) 和5.9% (非西班牙裔白人).
- 在最近患有缺血性中风的患者中,AF比例为32.2% (黑人),24.3% (亚洲人),25% (西班牙裔/拉丁裔) 和24.5% (非西班牙裔白人).
- 当假定AF监测 (例如,中风后) 时,少数群体和NHW人群之间的相对患病率差异缩小了,这表明确定偏差.
结论:
- 与非西班牙裔白人人口相比,美国少数群体的临床检测AF患病率较低.
- 鉴定偏差显著影响AF患病率估计,特别是在亚洲和西班牙裔/拉丁裔子组.
- 解决确定偏差对于准确的AF负担评估和公平的临床试验参与至关重要.
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