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Updated: Jun 28, 2025

Facile Protocol for the Synthesis of Self-assembling Polyamine-based Peptide Amphiphiles PPAs and Related Biomaterials
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超越N-化:N-氨基的合成,结构和功能

Isaac J Angera1, Madison M Wright1, Juan R Del Valle1

  • 1Department of Chemistry & Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, United States.

Accounts of chemical research
|April 16, 2024
PubMed
概括

N-氨基化稳定蛋白质结构,并产生可溶性粉样蛋白模仿物. 这种方法通过提高稳定性和准蛋白质-蛋白质相互作用来增强类药物设计.

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Alkylation is one of the methods used to prepare amines. Direct alkylation of ammonia or a primary amine with an alkyl halide gives polyalkylated amines along with a quaternary ammonium salt through successive SN2 reactions. This process of making the quaternary salt through the direct alkylation method is called exhaustive alkylation.
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