有证据表明,阴道感官神经参与流感病原和疾病的发生
Nathalie A J Verzele1,2, Brendon Y Chua3, Kirsty R Short1,4
1School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia Queensland, Australia.
PLoS pathogens
|April 16, 2024
概括
流感病毒感染会影响呼吸,导致严重的疾病. 肺部的阴道感觉神经元,当炎症时,会加剧这些临床症状,这表明流感的新治疗点.
科学领域:
- 神经免疫学 神经免疫学
- 呼吸系统医学 呼吸系统医学
- 传染性疾病 传染性疾病
背景情况:
- 全球范围内,A型流感病毒 (IAV) 导致严重的呼吸道疾病.
- 虽然IAV的免疫反应已知,但其神经免疫贡献尚不清楚.
研究的目的:
- 为了研究肺部阴道感觉神经元在IAV病变发生中的作用.
- 探索在IAV感染期间这些神经元和免疫反应之间的交叉声.
主要方法:
- 在小鼠的肺神经元中进行手术,遗传和药物学操纵.
- 用H1N1流感A病毒进行鼻腔内接种.
- 评估肺炎,病理和临床疾病迹象.
主要成果:
- IAV感染导致肺炎和严重疾病.
- 阴道感官神经元操纵适度影响肺炎,但恶化了临床症状.
- IAV感染诱导了阴道感觉神经炎症,由QX-314加剧,改变基因表达和增加炎症细胞.
结论:
- 肺部阴道感觉神经元在IAV感染期间调节炎症.
- 阴道神经炎症有助于IAV的发病和临床表现.
- 向阴道通路可能为IAV诱导的发病率和死亡率提供新的治疗方法.
相关概念视频
Immune Response Against Viral Pathogens
777
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
777
Leaky Scanning
5.1K
During most eukaryotic translation processes, the small 40S ribosome subunit scans an mRNA from its 5' end until it encounters the first start AUG codon. The large 60S ribosomal subunit then joins the smaller one to initiate protein synthesis. The location of the translation initiation is largely determined by the nucleotides near the start codon as there may be multiple translation initiation sites present on the mRNA. Marilyn Kozak discovered that the sequence RCCAUGG (where R...
5.1K
COPD: Pathogenesis and Clinical Features
267
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
267
Viral Recombination
23.4K
Cells are sometimes infected by more than one virus at once. When two viruses disassemble to expose their genomes for replication in the same cell, similar regions of their genomes can pair together and exchange sequences in a process called recombination. Alternatively, viruses with segmented genomes can swap segments in a process called reassortment.
23.4K
Pneumonia II: Pathophysiology
262
The pathophysiology of pneumonia involves the following steps:
262
Pathophysiology of Vomiting
419
Vomiting is a complex physiological response to expel harmful or irritating substances from the body. It's a defensive mechanism triggered by stimuli like poisons, microbial toxins, cytotoxic drugs, and mechanical abdominal distension. The process is centrally coordinated by the vomiting (or emetic) center located in the medulla of the brainstem. This area, rich in muscarinic M1, histamine H1, neurokinin 1 (NK1), and serotonin 5-HT3 receptors, coordinates the act of vomiting through...
419


