周血管空间,周血管空间沿线的扩散性,以及大脑小血管疾病中的自由水
Hao Li1, Mina A Jacob1, Mengfei Cai1
1From the Department of Neurology (H.L., M.A.J., M.C., F.-E.D.L., A.M.T.), Radboud University Medical Center, Donders Center for Medical Neurosciences, Nijmegen, the Netherlands; Department of Neurology (M.C.), Guangdong Neuroscience Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China; Donders Institute for Brain (R.P.C.K.), Cognition and Behaviour, Radboud University, Nijmegen; Vincent van Gogh Institute for Psychiatry (R.P.C.K.), Venray; Department of Medical Psychology and Radboudumc Alzheimer Center (R.P.C.K.), Radboud University Medical Center; Donders Institute for Brain (D.G.N.), Cognition and Behaviour, Center for Cognitive Neuroimaging, Radboud University, Nijmegen, the Netherlands; Medical Image Analysis Center (MIAC AG) and Department of Biomedical Engineering (M.D.), University of Basel, Switzerland; and Institute for Stroke and Dementia Research (ISD) (M.D.), University Hospital, LMU Munich, Germany.
大脑小血管疾病 (SVD) 的进展与周周血管空间 (PVS) 和自由水 (FW) 的增加以及沿周周血管空间 (DTI-ALPS) 的扩散性降低有关. 这些MRI标记物预测随着时间的推移,SVD患者的认知能力下降.
科学领域:
- 神经成像是一种神经成像.
- 脑血管疾病 脑血管疾病
- 认知神经学 认知神经学
背景情况:
- 大脑小血管疾病 (SVD) 与认知障碍有关.
- 周周血管空间 (PVS),周周血管空间 (DTI-ALPS) 和自由水 (FW) 等MRI测量与SVD相关.
- 对这些MRI标记物,SVD进展和认知衰退的纵向研究是有限的.
研究的目的:
- 调查PVS,DTI-ALPS和FW之间的纵向关联.
- 确定这些MRI标记物如何促进SVD进展.
- 探索它们对SVD患者认知衰退的影响.
主要方法:
- 一项对289名SVD参与者的队列研究,基线和随访神经影像和认知评估 (MMSE,认知指数,处理速度).
- 基底质PVS (BG-PVS) 量,FW分数和DTI-ALPS的量化.
- 隐性变化得分和线性回归混合模型被用于分析相互关系和纵向关联.
主要成果:
- 增加的BG-PVS,FW分数和减少的DTI-ALPS与SVDMRI标志物 (WMH,缺口,大脑体积) 的进展有关.
- 基线FW分数与MMSE得分下降相关.
- 无论是FW分数还是DTI-ALPS,都预测了随着时间的推移,认知指数和处理速度的变化.
结论:
- 升高的BG-PVS,增加的FW和减少的DTI-ALPS与SVD进展和认知衰退有关.
- 这些发现表明,淋巴功能障碍在SVD进展中起着作用.
- 需要进一步的研究来证实这些关联并探索治疗意义.
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