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Updated: May 5, 2026

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
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三级复杂模板动态组合化学用于选择和识别homo-PROTACs

Claudia J Diehl1, Alessandra Salerno1, Alessio Ciulli1

  • 1Centre for Targeted Protein Degradation, School of Life Sciences, University of Dundee, 1 James Lindsay Place, DD1 5JJ, Dundee, Scotland, U.K.

Angewandte Chemie (International ed. in English)
|April 16, 2024
PubMed
概括

动态组合化学 (DCC) 被调整为发现双功能蛋白解向嵌合体 (PROTACs). 这种新的方法使用三元复合形成来识别强大的Homo-PROTAC降解剂.

关键词:
这就是 PROTACs.这是VHLVHL.测试开发 测试开发动态组合化学 动态组合化学有针对性的蛋白质降解降解.

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