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在周心动期间,宫食道壁张力的生物机械增加
Ivan M Lang1, Bidyut K Medda1, Reza Shaker1
1Dysphagia Research Laboratory, Division of Gastroenterology and Hepatology, Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin, United States.
概括
宫食道的周围张力 (CTE) 在食道周平静期间由于纵向肌肉收缩而增加. 这种生物机械反应与食道缩短有关,而不是喉升高或肌肉活动.
科学领域:
- 胃肠病学 胃肠病学
- 生理学 生理学 生理学
- 生物力学 生物力学
背景情况:
- 吞涉及复杂的生物机械过程,包括食道张力的变化.
- 宫食道 (CTE) 的周围张力在喉阶段增加,这与喉升高有关.
- 消化管周平静涉及纵向肌肉收缩,促使对其对CTE的影响进行调查.
研究的目的:
- 通过生物机械过程测试CTE在食道周平静期间增加的假设.
- 阐明食道周静止,纵向张力和宫食道张力之间的关系.
主要方法:
- 使用了带有EMG电极,力度计和张力计的去脑猫来测量CTE,远隔食道纵向张力 (DET) 和前喉张力 (OLT).
- 通过注射盐水进行刺激周心静止,并研究了食神经 (PEN),下神经 (HG) 和六甲 (HEX) 的作用.
- 在刺激周立静脉运动期间分析了CTE,DET,OLT,EMG和测量力学之间的相关性.
主要成果:
- CTE和DET持续时间与食道周平静止同时增加;CTE持续时间与DET相关,但不与EMG或人计相关.
- 峰值DET和CTE的大小高度相关.
- 施用HEX可降低CTE反应持续时间,而PEN或HG切割并没有显著影响CTE.
结论:
- 在食道周静止过程中,CTE显著增加,独立于喉升高或食道肌肉收缩.
- 这种CTE反应是一种由食道在纵向收缩期间缩短而产生的生物机械效应.
- 这些发现表明,一种新的机制有助于食道机械在周围的过程中.
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