无法切除的胆道癌症:当前和未来的全身疗法
Danmei Zhang1, Klara Dorman1, C Benedikt Westphalen1
1Department of Medicine III, LMU University Hospital, LMU Munich and Comprehensive Cancer Center Munich, Marchioninistr. 15, 81377 Munich, Germany.
概括
晚期胆道癌 (BTC) 治疗现在包括免疫疗法和化学疗法之外的向疗法. 基因组评估对于个性化治疗不可切除的BTC至关重要.
科学领域:
- 在瘤学瘤学.
- 胃肠病学 胃肠病学
背景情况:
- 从历史上看,化疗是晚期胆道癌 (BTC) 的唯一治疗方法.
- 最近的进展引入了免疫疗法和针对不可切除的BTC的向疗法.
- 个性化瘤学在胃肠道恶性瘤中越来越重要.
研究的目的:
- 审查当前关于不可切割的BTC的知识.
- 专注于流行病学,解剖分布和全身治疗策略.
- 概述正在进行的临床试验和未来的治疗干预措施.
主要方法:
- 关于不可切除BTC的当前知识的文献综述.
- 系统性治疗策略的总结,包括化疗,免疫疗法和向治疗.
- 分析正在进行的临床试验和未来的方向.
主要成果:
- 无法切割的BTC的治疗环境已经显著扩大.
- 免疫治疗和向治疗现在是指导方针推的.
- 基于基因组的病理学评估对于个性化治疗至关重要.
结论:
- 无法切除的BTC的管理正在向个性化医学发展.
- 为了最佳的治疗选择,全面的基因组分析是必不可少的.
- 未来的干预措施有望改善患者的治疗结果.
相关概念视频
Targeted Cancer Therapies
7.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.6K
Tumor Immunotherapy
522
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
522
Chronic Pancreatitis II: Collaborative Care
86
The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
Assessment:
86


