固定的剂量胺素用于在医院前治疗过敏 Delirium 与严重动荡
Michael C O'Brien1, Kyle J Kelleran1, Susan J Burnett1
1Department of Emergency Medicine, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, USA.
The American journal of emergency medicine
|April 16, 2024
概括
一定剂量250毫克的胺有效地镇静了大多数患有严重兴奋过度活动妄想症 (HDSA) 的患者. 这种医院前的方案是基于体重的剂量替代方案,对不良事件的发生率很低,没有患者需要紧急医疗服务的输管治疗.
科学领域:
- 紧急医疗 紧急医疗
- 药理学 药理学是指药理学的学科.
- 关键的护理关键的护理
背景情况:
- 患有过敏狂妄症和严重动荡症 (HDSA) 的患者通常需要快速镇静以稳定和运输.
- 准确的基于体重的剂量可能在紧急医院前设置中具有挑战性.
- 固定剂量胺蛋白协议提供了一个潜在的替代方案,以减少剂量错误和提高效率.
研究的目的:
- 评估与HDSA医院前固定剂量胺剂的使用相关的不良事件的频率和特征.
- 为了在紧急情况下比较固定的剂量胺剂与传统的基于体重的剂量.
主要方法:
- 回顾四个机构紧急医疗服务 (EMS) 记录的回顾性审查.
- 纳入标准:成年患者接受250毫克固定的剂量凯胺治疗HDSA根据常务命令.
- 分析初始和总剂量,基于体重的相当剂量和不良事件,包括需要输管治疗.
主要成果:
- 60个病例符合纳入标准;患者中位体重为80公斤.
- 没有患者需要通过EMS进行输管;三人需要袋门口罩 (BVM) 支持.
- 在ED中,有6名患者 (10%) 接受了输管治疗;没有人经历了与第二剂胺相关的不良事件. 初始或总剂量与输管不相关.
结论:
- 250毫克固定的胺剂量对80%的HDSA患者有效,副作用最小.
- 固定剂量协议似乎是安全有效的,减少了对EMS输管的需要.
- 需要进一步的研究来优化固定剂量胺的HDSA协议,并评估它们对剂量错误的影响.
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