甲酸和甲甲酸比阿扎西奥普林在严重肌痛症中更好地耐受
Katherine C Dodd1, Rohan Ahmed2, Philip Ambrose3
1Manchester Centre for Clinical Neuroscience, Northern Care Alliance NHS Foundation Trust, Salford Royal, Stott Lane, Salford, M6 8HD, UK; The University of Manchester, Manchester Academic Health Science Centre, Core Technology Facility, Manchester, M13 9WU, UK.
阿扎西奥普林,基酸盐和甲铁酸盐是治疗肌痛性骨髓灰质炎的免疫抑制剂. 阿扎西奥普林的副作用和停药次数比mycophenolate和methotrexate更多,特别是在女性中.
科学领域:
- 神经学 神经学
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 骨髓灰质炎 (MG) 的管理通常涉及免疫抑制剂.
- 阿扎西奥普林是一种常见的第一线治疗方法,替代品是mycophenolate和methotrexate.
研究的目的:
- 为了比较真实世界的耐受性和停止阿扎西奥普林的原因,mycophenolate和美索特雷克萨特在MG患者.
- 为了确定这些免疫抑制剂所影响的特定副作用和患者人口统计数据.
主要方法:
- 进行了一项英国全国性的调查.
- 从235名MG患者中收集的数据,这些患者接受了阿扎西奥普林 (n=166),米可酸盐 (n=102) 和甲铁酸盐 (n=40).
- 分析的重点是报告的副作用和停止治疗的原因.
主要成果:
- 常见的副作用:阿扎西奥普林 (肝功能障碍,23%),美酸盐 (腹,14%),甲酸盐 (疲劳,18%).
- 与mycophenolate和methotrexate相比,由于副作用,阿扎西奥普林的停用频率更高.
- 由于缺乏疗效而停止治疗时没有观察到显著差异.
- 妇女报告副作用的发生率更高.
结论:
- 严重骨髓灰质炎的免疫抑制治疗带来了相当大的副作用负担.
- 甲酸和甲铁酸的耐受性比阿扎西奥普林更好,特别是如果致性不是一个问题.
- 需要对改善耐受性的治疗方法进行进一步的研究,特别是考虑到性别特定的副作用概况和生殖问题.
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