制备pH值敏感的多孔多乳酸医疗包裹,具有自功能
Zijian Zhang1, Jianyong Li1, Yi Wang2
1Key Laboratory of High Efficiency and Clean Mechanical Manufacture, Ministry of Education, School of Mechanical Engineering, Shandong University, Jinan 250061, China; National Demonstration Center for Experimental Mechanical Engineering Education, Shandong University, Jinan 250061, China.
International journal of biological macromolecules
|April 16, 2024
概括
这项研究开发了一种新型的pH敏感伤口包裹,使用静电线. 自动抽包装改变颜色以表明愈合状态,提供更好的慢性伤口管理.
科学领域:
- 生物材料科学 生物材料科学
- 伤口愈合技术 伤口愈合技术
- 聚合物化学 聚合物化学
背景情况:
- 慢性伤口由于过度排泄和难以评估愈合而带来了重大管理挑战.
- 目前的伤口包裹往往缺乏提供实时愈合状态指标的能力.
- 开发先进的伤口护理解决方案对于改善患者治疗结果至关重要.
研究的目的:
- 制造一种具有多功能,pH值敏感,色度测量的慢性伤口带,具有自能力.
- 利用静电技术,创建一个多层的伤口带.
- 评估包裹在治疗慢性伤口方面的有效性.
主要方法:
- 三层料的制造:聚乳酸-黄素 (PCL-LLA) 水层,水解聚烯 (HPAN) 转移层和聚烯 (PAN-PCA) 水层.
- 利用静电来制造带有素 (Cur) 的多孔PLLA纤维膜,具有抗炎,抗菌和抗氧化特性.
- 优化HPAN膜处理,以增强液体浸湿和单向运输,结合PCPLLA和PAN-PCA层用于色度pH传感.
主要成果:
- 成功制备了带有Cur (0.2%) 的多孔PLLA纤维膜,显示出所需的治疗性质.
- 用处理的HPAN膜显示出增强的液体浸湿性和单向传输能力.
- PAN-PCA层含有4%加载的紫色胡卜类抗生素 (PCA) 显示出对pH值变化有明显的色度反应,表明了伤口状态.
结论:
- 开发的多功能带显示了有效的慢性伤口管理的潜力.
- 自动抽,pH值敏感,色度特征为伤口护理技术提供了有前途的进步.
- 在体内和体外的研究支持这种新型伤口带的临床适用性.
相关概念视频
pH
The potential of hydrogen (pH) is a measure of the acidity or basicity of a water-based solution determined by the concentration of hydronium ions (H3O+). In one liter of pure water at neutral pH, there are 1×10−7 moles of hydronium ions. However, the extensive range of hydronium ion concentrations present in water-based solutions makes measuring pH in moles cumbersome. Therefore, a pH scale was developed to convert moles of hydronium ions into the negative logarithm of the hydronium ion...
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The human body carefully regulates the internal pH of different organs to maintain homeostasis. For example, while the blood plasma maintains a neutral pH of 7, the stomach lumen has an acidic pH of 1.5 - 3.5. The low pH of stomach lumen helps kill pathogens in the food and break down complex food molecules.
The acid-secreting gastric mucosal epithelial cells (parietal cells) lining the stomach lumen maintain the low pH in the lumen. Numerous ion transporters and channels on these parietal...
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