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Kale S Bongers¹, Angeline Massett¹, David N O'Dwyer¹

¹Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan.

Seminars in respiratory and critical care medicine

|April 16, 2024

概括

口腔和肺部的微生物群可能会影响连接组织疾病相关的间歇性肺病 (CTD-ILD). 研究表明,改变的口腔和肺部细菌有助于CTD-ILD的发展和进展.

科学领域:

微生物学微生物学
免疫学免疫学免疫学
类风湿病学类风湿病学

背景情况:

连接组织疾病相关的间歇性肺病 (CTD-ILD) 是连接组织疾病 (CTD) 的严重并发症.
确切的CTD-ILD的原因尚未完全理解,但口腔和肺部微生物组正在成为潜在的因素.
改变的口腔微生物群可以通过微吸影响肺微生物群,影响患有间歇性肺病 (ILD) 的患者.

研究的目的:

审查CTD-ILD中口腔和肺微生物群失生症的当前数据.
探索微生物变化的潜在作用在CTD-ILD的致病性.
确定未来的研究方向,以了解微生物组对CTD-ILD的贡献.

主要方法:

关于CTD-ILD和微生物组变化的现有研究的文献综述.
分析数据,将口腔和肺部微生物群的变化与ILD中的免疫反应联系起来.
专注于特定的CTD:类风湿性关节炎,Sjögren综合征,全身性硬化和全身性红斑狼.

主要成果:

有证据表明,ILD患者的口腔和肺微生物组存在失调 (不平衡).
口腔和肺部微生物群的变化与肺部免疫反应的改变有关.
微生物群失生症与多种自身免疫性疾病中CTD-ILD的发病有关.

结论:

口腔和肺部微生物组是CTD-ILD的一个重要,但尚未研究的因素.
准微生物失生症可能为CTD-ILD提供新的治疗策略.
进一步的研究至关重要,以阐明微生物群影响CTD-ILD发育和进展的确切机制.

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