在患有全身性红斑狼的个体中比较认知性能指标
Laura Plantinga1, Jinoos Yazdany2, C Barrett Bowling3,4
1Department of Medicine, University of California San Francisco, San Francisco, California, USA laura.plantinga@ucsf.edu.
Lupus science & medicine
|April 16, 2024
概括
系统性红斑狼 (SLE) 患者在多项测试中显示认知障碍. 步道制作测试B (TMTB) 和时钟绘图测试 (CLOX) 发现了比NIH工具箱流体认知电池更多的损伤.
科学领域:
- 类风湿病学 类风湿病学
- 神经科学是一个神经科学.
- 认知心理学 认知心理学
背景情况:
- 认知障碍是系统性红斑狼 (SLE) 患者经常抱怨的一种情况.
- 对SLE认知表现的客观测量方法有很大的差异.
- 这项研究解决了在SLE人群中标准化认知评估的需要.
研究的目的:
- 在基于人口的SLE队列中,在多个客观措施中比较认知表现和潜在损伤.
- 确定最敏感的认知评估工具,用于检测SLE患者的损伤.
主要方法:
- 在423名SLE患者中记录了Trail Making Test B (TMTB) 完成时间.
- 对435名SLE患者 (CLOX1和CLOX2) 进行了时钟绘图测试 (CLOX).
- 国家卫生研究院 (NIH) 工具箱流体认知电池评估了199名SLE患者.
主要成果:
- 潜在损伤的患病率为TMTB的65%,CLOX的55%,NIH工具箱的28%.
- TMTB时间和流体认知得分显示出强烈的负相关性 (ρ=-0.53,p<0.001).
- 在TMTB和CLOX之间观察到显著的损伤重叠,其中58%只在一个测试中表现出损伤.
结论:
- TMTB,CLOX和NIH流体认知电池都为SLE认知表现提供了独特的见解.
- 这些测量对评估SLE的认知功能有潜在的价值.
- 需要进一步的研究来验证这些认知评估,并为SLE患者开发干预措施.
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