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人类血脑屏障模型的神经疾病中的分子运输和治疗发展的进展
Joanna Korszun-Karbowniczak1,2, Zuzanna Joanna Krysiak3, Joanna Saluk4
1Laboratory of Molecular Oncology and Innovative Therapies, Military Institute of Medicine National Research Institute, 128 Szaserów Street, 04-141, Warsaw, Poland.
Cellular and molecular neurobiology
|April 16, 2024
概括
了解血脑屏障 (BBB) 对中枢神经系统健康至关重要. 本综述涵盖了BBB的结构,功能,功能障碍以及药物开发的体外模型.
科学领域:
- 神经科学是一个神经科学.
- 生物医学工程 生物医学工程
背景情况:
- 血脑屏障 (BBB) 通过调节物质通道来维持中枢神经系统 (CNS) 的稳态.
- 对于理解大脑生理学和病理学而言,BBB透性至关重要.
- 在体外模型对于研究BBB机制和开发向中枢神经系统的药物至关重要.
研究的目的:
- 介绍BBB的结构,分子特征和功能障碍.
- 描述目前用于BBB研究的体外建模策略.
- 突出BBB模型在促进中枢神经系统药物开发中的作用.
主要方法:
- 审查关于BBB结构,功能和建模的现有文献.
- 讨论各种体外BBB模型,包括单层,跨井,母,球形和组织在芯片平台.
- 在衰老,神经退行,缺氧和神经毒性条件下分析BBB功能障碍.
主要成果:
- 详细介绍BBB结构和分子特征.
- 在各种病理条件下解释BBB功能障碍.
- 目前的体外BBB模型及其应用的概述.
结论:
- 了解BBB结构和功能对于中枢神经系统研究至关重要.
- 试验室BBB模型是研究屏障机制和药物输送的必不可少的工具.
- 先进的BBB模型有助于开发新的中枢神经系统疗法.
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